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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Author: <span>admin</span>

Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. J Neurosci 2016 36:2391-405.

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EphA4 is involved in sleep regulation but not in the electrophysiological response to sleep deprivation

Sleep

Freyburger M, Pierre A, Paquette G, Belanger-Nelson E, Bedont J, Gaudreault P-O, Rolet G, Laforest S, Blackshaw S, Cermakian N, Doucet G, and Mondrain V. Sleep 2016 39:613-24.

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Regulation of body weight and metabolism by tanycyte-derived neurogenesis in young adult mice

Hypothalamus, Neurogenesis, Tanycytes

Blackshaw S, Lee DA, Pak T, and Yoo S. In Stem Cells in Neuroendocrinology, Springer, 2016.

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A conserved regulatory logic controls temporal identity in mouse neural progenitors

Cell fate, Development, Retina, Transcription factor

Mattar P, Ericson J, Blackshaw S, and Cayouette M. Neuron 2015 85:497-504.

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Identification of SUMO E3 Ligase Specific Substrates Using Human Proteome Microarrays

Protein microarray, Proteomics, Protocol, SUMOylation

Cox E, Uzoma I, Guzzo CM, Jeong JS, Matunis M, Blackshaw S and Zhu H. Methods Mol Biol 2015 295:455-63.

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Large-scale in situ hybridization in developing mouse diencephalon

Protocol, Transcriptomics

Shimogori T and Blackshaw S. Neuromethods 2015 99:307-220.

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Molecular mechanisms controlling hypothalamic development

Development, Hypothalamus, Neurogenesis, Review article, Spatial patterning

Bedont JL, Blackshaw S, and Newman EA. Wiley Interdisciplinary Reviews: Developmental Biology, 2015 10.1002/wdev.18

The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation

Cell fate, Development, Lhx2, Tanycytes, Transcription factor

Salvatierra J, Lee DA, Zibetti C, Duran-Moreno M, Yoo S, Newman EA, Wang H, Bedont JL, de Melo J, Miranda-Angulo AL, Gil-Perotin S, Garcia-Verdugo JM, and Blackshaw S. J Neurosci 2014 34:16809-20.

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Development of hypothalamic neural circuitry controlling circadian timing and sleep

Circadian, Development, Hypothalamus, Sleep

Bedont JL and Blackshaw S. Frontiers in Neuroscience, 2015 9:74.

Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer

Notch/Delta, Protein microarray, Proteomics, Signal transduction

Jung J, Stoeck A, Guan B, Wu RC, Zhu H, Blackshaw S, Shih IM, and Wang TL. PLoS Genetics 2014 10:e1004751.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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