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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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  • Publications
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  • Datasets & Techniques

Category: <span>Circadian</span>

Winding the clock: development of hypothalamic neural circuitry controlling circadian timing and sleep

Circadian, Development, Hypothalamus, Review article, Sleep, Transcription factor

Kim DW and Blackshaw S. Masterclass in Developmental Neuroendocrinology, Springer, in press.

Asymmetric vasopressin signaling organizes the master circadian clock

Circadian, Suprachiasmatic nucleus

Bedont JL, Rohr KE, Bathini A, Hattar S, Blackshaw S, Seghal A, and Evans JA. J Comp Neurol 2018 doi:10.1002/cne.24478.

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An Lhx1-Regulated Transcriptional Network Controls Sleep-Wake Coupling and Thermal Resistance of the Central Circadian Clockworks

Circadian, Hypothalamus, Sleep

Bedont JL, LeGates TA, Buhr E, Bathini A, Ling J, Wong P, van Gelder R, Mongrain V, Hattar S, and Blackshaw S. Curr Biol 2017 27:128-136.

Link to Article>> View PDF>>

Development of hypothalamic neural circuitry controlling circadian timing and sleep

Circadian, Development, Hypothalamus, Sleep

Bedont JL and Blackshaw S. Frontiers in Neuroscience, 2015 9:74.

Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus

Circadian, Development, Hypothalamus, Nucleogenesis, Suprachiasmatic nucleus, Transcription factor

Bedont JL, LeGates TA, Slat EA , Byerly MS, Wang H, Hu J, Rupp AC, Qian J, Wong GW, Herzog ED, Hattar S, and Blackshaw S. Cell Reports 2014 7:609-22.

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Muscleblind-like 2: Circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism

Circadian, RNA binding proteins, Signal transduction

Kim JS, Coon SL, Weller JL, Blackshaw S, Rath MF, Mrller M, Klein DC. J Neurochem 2009 110:756-64.

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Methionine Adenosyltransferase (MAT): Adrenergic-cyclic AMP Mechanism Mediates Control of a Daily Rhythm in Pineal Expression

Circadian, Signal transduction

Kim JS, Coon SL, Blackshaw S, Cepko CL, Moller M, Mukda S, Zhao W-Q, Charlton CG, Klein DC. J Biol Chem 2005; 280:677-84.

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Circadian rhythm of patched1 transcription in the pineal regulated by adrenergic stimulation and cAMP

Circadian, Signal transduction

Borjigin J, Deng J, Wang MM, Li,X, Blackshaw S, Snyder SH. J Biol Chem 1999 274: 35012-35016.

Link to Article>> View PDF>>

Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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