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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Category: <span>Development</span>

The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis

Cell fate, Development, Lhx2, Neurogenesis, Retina

Gueta K, Cohen T, David A, Nobel H, Narkis G, Li L, Love P, de Melo J, Blackshaw S, Westphal H, and Ashery-Padan R. Development 2016 143:4182-4192.

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Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Clark BS, and Blackshaw S. Sci Reports 2016 6:32757.

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Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. J Neurosci 2016 36:2391-405.

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A conserved regulatory logic controls temporal identity in mouse neural progenitors

Cell fate, Development, Retina, Transcription factor

Mattar P, Ericson J, Blackshaw S, and Cayouette M. Neuron 2015 85:497-504.

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Molecular mechanisms controlling hypothalamic development

Development, Hypothalamus, Neurogenesis, Review article, Spatial patterning

Bedont JL, Blackshaw S, and Newman EA. Wiley Interdisciplinary Reviews: Developmental Biology, 2015 10.1002/wdev.18

The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation

Cell fate, Development, Lhx2, Tanycytes, Transcription factor

Salvatierra J, Lee DA, Zibetti C, Duran-Moreno M, Yoo S, Newman EA, Wang H, Bedont JL, de Melo J, Miranda-Angulo AL, Gil-Perotin S, Garcia-Verdugo JM, and Blackshaw S. J Neurosci 2014 34:16809-20.

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Development of hypothalamic neural circuitry controlling circadian timing and sleep

Circadian, Development, Hypothalamus, Sleep

Bedont JL and Blackshaw S. Frontiers in Neuroscience, 2015 9:74.

Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus

Circadian, Development, Hypothalamus, Nucleogenesis, Suprachiasmatic nucleus, Transcription factor

Bedont JL, LeGates TA, Slat EA , Byerly MS, Wang H, Hu J, Rupp AC, Qian J, Wong GW, Herzog ED, Hattar S, and Blackshaw S. Cell Reports 2014 7:609-22.

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Long noncoding RNA-dependent transcriptional regulation in neuronal development and disease

Development, lncRNAs, Review article

Clark BS and Blackshaw S. Frontiers in Genetics, 2014 5:164.

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Feed your head: neurodevelopmental regulation of metabolism

Development, Hypothalamus, Neurogenesis, Review article

Lee DA and Blackshaw S. Annual Review of Physiology, 2014 76:197-223.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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