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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Category: <span>Hypothalamus</span>

The nutrient sensor OGT in PVN neurons regulates feeding

Hypothalamus, Metabolism

Lagerlöf O, Slocomb JE, Hong I, Aponte Y, Blackshaw S, Hart GW and Huganir RL. Science 2016 351:1293-6.

Link to Article>> View PDF>>

Regulation of body weight and metabolism by tanycyte-derived neurogenesis in young adult mice

Hypothalamus, Neurogenesis, Tanycytes

Blackshaw S, Lee DA, Pak T, and Yoo S. In Stem Cells in Neuroendocrinology, Springer, 2016.

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Molecular mechanisms controlling hypothalamic development

Development, Hypothalamus, Neurogenesis, Review article, Spatial patterning

Bedont JL, Blackshaw S, and Newman EA. Wiley Interdisciplinary Reviews: Developmental Biology, 2015 10.1002/wdev.18

Development of hypothalamic neural circuitry controlling circadian timing and sleep

Circadian, Development, Hypothalamus, Sleep

Bedont JL and Blackshaw S. Frontiers in Neuroscience, 2015 9:74.

Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice

Hypothalamus, Neurogenesis, Tanycytes

Lee DA, Yoo S, Pak T, Salvatierra J, Velarde E, Aja S, and Blackshaw S. Front Neurosci 2014 8:15

Link to Article>> View PDF>>

Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus

Circadian, Development, Hypothalamus, Nucleogenesis, Suprachiasmatic nucleus, Transcription factor

Bedont JL, LeGates TA, Slat EA , Byerly MS, Wang H, Hu J, Rupp AC, Qian J, Wong GW, Herzog ED, Hattar S, and Blackshaw S. Cell Reports 2014 7:609-22.

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WIDE AWAKE mediates the circadian timing of sleep onset

Hypothalamus, Sleep

Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont JL, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K, and Wu MN. Neuron 2014 82:151-6.

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Rax-CreERT2 knock-in mice: a tool for selective and conditional gene deletion in progenitors and radial glia of the retina and hypothalamus

Cell lineage analysis, Hypothalamus, Radial glia, Retina, Tanycytes

Pak T, Yoo SY, Miranda-Angulo AM, Wang H, and Blackshaw S. PLoS ONE 2014, 9:e90381.

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Feed your head: neurodevelopmental regulation of metabolism

Development, Hypothalamus, Neurogenesis, Review article

Lee DA and Blackshaw S. Annual Review of Physiology, 2014 76:197-223.

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Probing the functional role of adult hypothalamic neurogenesis by computer tomography image guided focal irradiation

Hypothalamus, Neurogenesis, Protocol

Lee DA, Salvatierra J, Velarde E, Wong J, Ford E, Blackshaw S. JoVE 2013 14: 10.379/50716.

Link to Article>> View PDF>>

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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