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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Category: <span>Metabolism</span>

Ablation of tanycytes of the arcuate nucleus and median eminence increases visceral adiposity and decreases insulin sensitivity in male mice

Hypothalamus, Metabolism, Tanycytes

Yoo S, Cha D, Kim S, Jiang L, Adebesin M, Wolfe A, Riddle R, Aja S, and Blackshaw S. PNAS, under review.

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Tanycyte-independent regulation of hypothalamic leptin signaling

Hypothalamus, Metabolism, scRNA-Seq, Tanycytes

Yoo S, Cha D, Kim DW, Hoang T, and Blackshaw S. Frontiers in Neuroscience, in press.

The nutrient sensor OGT in PVN neurons regulates feeding

Hypothalamus, Metabolism

Lagerlöf O, Slocomb JE, Hong I, Aponte Y, Blackshaw S, Hart GW and Huganir RL. Science 2016 351:1293-6.

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Stage-specific inhibition of TrkB leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression

Metabolism, Signal transduction

Byerly MS, Swanson R, Wong GW and Blackshaw S. PLoS ONE 2013 8:e80781.

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ERRb deficiency alters body composition and response to stress

Metabolism, Transcription factor

Byerly MS, Swanson R, Wong GW, Blackshaw S. BMC Physiology 2013 13:10.

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Hypothalamic Neuron-derived Neurotrophic Factor (NENF) interacts with BDNF and melanocortin signaling to modulate food intake

Hypothalamus, Metabolism, Signal transduction

Byerly MS, Swanson R, Kwon K, Aja S, Moran TH, Wong GW, Blackshaw S. Am J Physiol 2013 304:R1085-95.

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Estrogen-related receptor β regulates whole body energy balance and modulates neuropeptide Y expression

Metabolism, Transcription factor

Byerly MS, Al Salayta M, Kwon K, Swanson R, Peterson JM, Wei Z, Aja S, Moran TH, Blackshaw S, Wong GW. Eur J Neurosci 2013 37:1033-47.

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Tanycytes of the median eminence form a dietary-responsive neurogenic niche

Cell lineage analysis, Hypothalamus, Metabolism, Neurogenesis, Radial glia, Tanycytes

Lee DA, Pak T, Bedont JL, Wang H, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Fishell G, Ford E and Blackshaw S. Nat Neurosci 2012 15:700-2.

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Differential expression of putative transbilayer amphipath transporters

Metabolism, Signal transduction

Halleck MS, Lawler JF Jr, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Nakanashi Y, Ando,H, Weinstock D, Williamson P, Schlegel RA. Physiol Genomics 1999 1:139-150.

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Interaction of RAFT1 with the clustering protein gephyrin required for rapamycin-sensitive signaling

Metabolism, Signal transduction

Sabatini DM, Barrow RK, Blackshaw S, Fields M, Kirsch J, Betz H, Snyder SH. Science 1999 294:1161-64.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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