Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy

Muller glia, Neurodegeneration, Neurogenesis, Notch/Delta, Photoreceptor, Retina, scRNA-Seq, , , , , ,

Fogerty, J., Song, P., Boyd, P., Grabinski, S. E., Hoang, T., Reich, A., Cianciolo, L. T., Blackshaw, S., Mumm, J. S., Hyde, D. R., & Perkins, B. D. (2022). Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(26), 5144–5158. https://doi.org/10.1523/JNEUROSCI.0244-22.2022

Link to Article>> View PDF>>

In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

Neurodegeneration, Photoreceptor, Retina, scRNA-Seq, , ,

Choi, E. H., Suh, S., Foik, A. T., Leinonen, H., Newby, G. A., Gao, X. D., Banskota, S., Hoang, T., Du, S. W., Dong, Z., Raguram, A., Kohli, S., Blackshaw, S., Lyon, D. C., Liu, D. R., & Palczewski, K. (2022). In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nature communications, 13(1), 1830. https://doi.org/10.1038/s41467-022-29490-3

Link to Article>> View PDF>>

Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration

Neurodegeneration, Retina,

Shah, S. H., Schiapparelli, L. M., Ma, Y., Yokota, S., Atkins, M., Xia, X., Cameron, E. G., Huang, T., Saturday, S., Sun, C. B., Knasel, C., Blackshaw, S., Yates, J. R., Cline, H. T., & Goldberg, J. L. (2022). Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration. eLife, 11, e68148. https://doi.org/10.7554/eLife.68148

Link to Article>> View PDF>>

Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinas

Neural development, Neurodegeneration, Neurogenesis, Retina, scRNA-Seq, Transcriptomics

Hoang TV, Wang J, Boyd P, Wang F, Santiago C, Jiang L, Lahne M, Todd LJ, Saez C, Yoo S, Keuthan C, Palazzo I, Squires N, Campbell WA, Jia M, Rajaii F, Parayil T, Wang G, Ash J, Fischer AJ, Hyde DR, Qian J, Blackshaw S.

Link to Article>> View PDF>>