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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Category: <span>Neurodegeneration</span>

The orphan nuclear hormone ERRb regulates rod photoreceptor development and survival

Neurodegeneration, Photoreceptor, Retina, Transcription factor

Onishi A, Peng G-H, Chen J, Lee DA, Alexis, U, Poth E, de Melo J, Chen S, and Blackshaw S. Proc Natl Acad Sci USA 2010 107:11579-84.

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The inherited blindness associated protein, AIPL1, interacts with the cell-cycle regulator protein, NUB1

Neurodegeneration, Photoreceptor, Retina

Akey DT, Zhu X, Dyer M, Li A, Sorensen A, Blackshaw S, Fukuda-Kamitani T, Daiger SP, Craft C, Kamitani T, Sohocki MM. Hum Mol Genet 2002 11:2723-33.

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Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa

Human genetics, Neurodegeneration, Photoreceptor

Browne SJ, Sullivan LS, Blanton SH, Cepko CL, Blackshaw S, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP. Hum Mol Genet 2002 11:559-568.

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Comprehensive analysis of photoreceptor gene expression and the identification of candidate retinal disease genes

Human genetics, Neurodegeneration, Photoreceptor, Retina, SAGE, Transcriptomics

Blackshaw S, Fraioli RE, Furukawa T, Cepko CL. Cell 2001 107:579-89.

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Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemia

Neurodegeneration, Signal transduction

Dore S, Goto S, Sampei K, Blackshaw S, Hester LD, Ingi T, Sawa A, Traystman RJ, Koehler RC, Snyder SH. Neuroscience 2000 99:587-92.

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Type 3 inositol 1,4,5-triphosphate receptor modulates cell death

Neurodegeneration, Signal transduction

Blackshaw S, Sawa A, Snyder SH, Khan A. FASEB J 2000 14:1375-1379.

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Mutations in a new photoreceptor-pineal gene on 17p cause Leber’s congenital amaurosis

Human genetics, Neurodegeneration, Retina

Sohocki M M, Bowne SJ, Sullivan LS, Blackshaw S, Cepko CL, Payne AM, BhattacharyaSS, Khaliq S, Qasim Mehdi S, Birch DG, Harrison WR, Elder FF, Heckenlively JR, Daiger SP. Nat Genet 2000 24:79

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Heme oxygenase-2 is neuroprotective in focal cerebral ischemia

Neurodegeneration, Neurotransmitters

Dore S, Sampi K, Goto S, Alkayed NJ, Blackshaw S, Gallagher M, Traysman RJ, Hurn PD, Guastella D, Koehler RC, Snyder SH. Mol Med 1999; 5:656-663.22.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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