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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Category: <span>Neurogenesis</span>

Regulation and function of neurogenesis in adult mammalian hypothalamus

Hypothalamus, Neurogenesis, Tanycytes

Yoo S and Blackshaw S. Progress in Neurobiology 2018 170:53-66.

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The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis

Cell fate, Development, Lhx2, Neurogenesis, Retina

Gueta K, Cohen T, David A, Nobel H, Narkis G, Li L, Love P, de Melo J, Blackshaw S, Westphal H, and Ashery-Padan R. Development 2016 143:4182-4192.

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Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Clark BS, and Blackshaw S. Sci Reports 2016 6:32757.

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Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. J Neurosci 2016 36:2391-405.

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Regulation of body weight and metabolism by tanycyte-derived neurogenesis in young adult mice

Hypothalamus, Neurogenesis, Tanycytes

Blackshaw S, Lee DA, Pak T, and Yoo S. In Stem Cells in Neuroendocrinology, Springer, 2016.

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Molecular mechanisms controlling hypothalamic development

Development, Hypothalamus, Neurogenesis, Review article, Spatial patterning

Bedont JL, Blackshaw S, and Newman EA. Wiley Interdisciplinary Reviews: Developmental Biology, 2015 10.1002/wdev.18

Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice

Hypothalamus, Neurogenesis, Tanycytes

Lee DA, Yoo S, Pak T, Salvatierra J, Velarde E, Aja S, and Blackshaw S. Front Neurosci 2014 8:15

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Feed your head: neurodevelopmental regulation of metabolism

Development, Hypothalamus, Neurogenesis, Review article

Lee DA and Blackshaw S. Annual Review of Physiology, 2014 76:197-223.

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Probing the functional role of adult hypothalamic neurogenesis by computer tomography image guided focal irradiation

Hypothalamus, Neurogenesis, Protocol

Lee DA, Salvatierra J, Velarde E, Wong J, Ford E, Blackshaw S. JoVE 2013 14: 10.379/50716.

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Tanycytes of the median eminence form a dietary-responsive neurogenic niche

Cell lineage analysis, Hypothalamus, Metabolism, Neurogenesis, Radial glia, Tanycytes

Lee DA, Pak T, Bedont JL, Wang H, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Fishell G, Ford E and Blackshaw S. Nat Neurosci 2012 15:700-2.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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