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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Category: <span>Protein microarray</span>

Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers in ZNF261 and ZNF198

Protein microarray, Proteomics, SUMOylation

Guzzo CM, Ringel A, Cox E, Uzoma I, Zhu H, Blackshaw S, Wolberger C, and Matunis MJ. 2014 PLoS ONE 2014 9:e105271.

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RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention

Neurodegeneration, Protein microarray, Proteomics, RNA binding proteins

Donnelly CJ, Zhang P, Pham JT, Heusler A, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Margakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennet CF, Blackshaw S, Sattler R, and Rothestein JD. Neuron 2013 80:415-28.

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Characterization of the S-Nitrosoproteome reveals an S-Nitrosylation Motif and a family of NO-regulated E3 ubiquitin ligases

Nitric oxide, Protein microarray, Proteomics

Lee YI, Giovinazzo D, Kang HC, Lee Y, Jeong JS, Doulias PT, Xie Z, Ischiropoulos H, Zhu H, Blackshaw S, Dawson VL, Dawson TM. Mol Cell Proteomics 2013 13:63-72

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BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity

Protein microarray, Proteomics

Chen Y, Yang LN, Cheng L, Shun T, Guo SJ, Le HY, Xiong Q, Mo R, Li CY, Jeong JS, Jiang L, Blackshaw S, Bi LJ, Zhu H, Tao SC, Ge F. Mol Cell Proteomics 2013 12:2804-19.

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The long non-coding RNA Gomafu is involved in neuronal activation and schizophrenia-associated alternative splicing

lncRNAs, Protein microarray

Barry G, Briggs J, Poth EM, Vanichkina , Ratnu VS, Nayler SP, Nones K, Bredy TW, Nakagawa S, Blackshaw S, Wolvetang EJ, Mattick JS. Mol Psych 2013 19:486-94.

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Construction of human activity-based phosphorylation networks

Protein microarray, Proteomics, Signal transduction

Newman RH, Hu J, Rho H-S, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Hu S, Hwang W, Jeong JS, Wu G, Jimmy Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov A, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J. Mol Sys Biol 2013 9:655.

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Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays

Antibody specificity, Autoimmune disease, Protein microarray, Proteomics

Hu CJ, Song G, Huang W, Liu GZ, Deng CW, Zeng HP, Wang L, Zhang FC, Zhang X, Jeong JS, Blackshaw S, Jiang LZ, Zhu H, Wu L, Li YZ. Mol Cell Proteomics 2012 11:669-80.

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A human proteome microarray-based pipeline for efficient production of monospecific monoclonal antibodies

Antibody specificity, New technique, Protein microarray, Proteomics

Jeong JS, Jiang L, Albino E, Marrero J, Rho HS, Hu S, Woodard C, Vera C, Bayron-Poueymirou D, Rivera-Pacheco ZA, Ramos L, Torres-Castro C, Bonaventura J, Boeke JD, Pino I, Eichinger DJ, Zhu H and Blackshaw S. Mol Cell Proteomics 2012 11:O111.016253.

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Multi-faceted Regulation of Protein Kinase CK2 by Phosphorylation and Glycosylation Revealed through Semisynthesis

Protein microarray, Proteomics, Signal transduction

Tarrant MK, Rho HS, Xie Z , Jiang L, Gross C, Qian J, Ichikawa Y, Zachara N, Etzkorn F, Hart GW, Jeong JS, Blackshaw S, Zhu H, Cole PA. Nat Chem Biol 2012 8:262-91.

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Characterization of protein-DNA interactions using protein microarrays

Protein microarray, Protocol

Hu S, Xie Z, Blackshaw S, Qian J, Zhu H. Cold Spring Harb Protoc, 2011 pii.pdb.prot5614.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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