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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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  • Datasets & Techniques

Category: <span>Retina</span>

Reactive microglia influence neuronal survival and NFkB signaling in damaged mouse retina

Neurodegeneration, Photoreceptor, Retina, scRNA-Seq

Todd L, Suarez L, Palazzo I, Fritsch-Kelleher A, Volkov L, Hoang T, Blackshaw S and Fischer AJ. J Neuroinflammation, under review.

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Comprehensive analysis of retinal development at single cell resolution identifies NFI factors as essential for mitotic exit and specification of late-born cells

Cell fate, Development, Neurogenesis, Retina, scRNA-Seq, Transcription factor, Transcriptomics

Clark BS, Stein-O’Brien GL, Shiau F, Cannon GH, Davis E, Sherman T, Rajaii F, James-Esposito RE, Gronostajski RM, Fertig EJ, Goff LA, and Blackshaw S. Neuron, in press.

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Epigenomic profiling of retinal progenitors reveals LHX2 is required for developmental regulation of open chromatin

ATAC-Seq, ChIP-Seq, Development, Lhx2, Retina, Transcription factor

Zibetti C, Liu S, Wan J, Qian J, and Blackshaw S. Comm Biology 2019, 2:142.

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Conditional deletion of DES1 in retina does not impair the visual cycle in cones

Photoreceptor, Retina, scRNA-Seq, Visual cycle

Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, and Palczewski K. FASEB J 2019 fj201802493R. doi: 10.1096/fj.201802493R (e-pub ahead of print).

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A widespread decrease in chromatin accessibility in age-related macular degeneration

ATAC-Seq, Neurodegeneration, Photoreceptor, Retina, RPE

Wang J, Zibetti C, Shang P, Sripathi SR, Zhang P, Cano M, Ji H, Merbs SL, Zack DJ, Handa J, Sinha D, Blackshaw S* and Qian J*. Nat Comm 2018 9:1364 (* indicates co-corresponding author).

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Ldb1 and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in retina

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Retina

de Melo J, Venkataraman A, Clark BS, Shiau F, Zibetti C, and Blackshaw S. Development 2018 145. pii: dev159970. doi: 10.1242/dev.159970

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Pax6 is essential for generation of late born retinal neurons and for inhibition of photoreceptor fate during late stages of retinogenesis in mammals

Cell fate, Development, Retina, Transcription factor

Remizova L Onishi A, Blackshaw S, Zack D, and Ashery-Padan R. Dev Biol 2017 432:140-150.

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The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis

Cell fate, Development, Lhx2, Neurogenesis, Retina

Gueta K, Cohen T, David A, Nobel H, Narkis G, Li L, Love P, de Melo J, Blackshaw S, Westphal H, and Ashery-Padan R. Development 2016 143:4182-4192.

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Control of lens development by Lhx2- regulated neuroretinal FGFs

FGF, Lens, Lhx2, Retina

Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, and Blackshaw S. Development 2016 143: 3994-4002.

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Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Clark BS, and Blackshaw S. Sci Reports 2016 6:32757.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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