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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Category: <span>Retina</span>

Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. J Neurosci 2016 36:2391-405.

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A conserved regulatory logic controls temporal identity in mouse neural progenitors

Cell fate, Development, Retina, Transcription factor

Mattar P, Ericson J, Blackshaw S, and Cayouette M. Neuron 2015 85:497-504.

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Rax-CreERT2 knock-in mice: a tool for selective and conditional gene deletion in progenitors and radial glia of the retina and hypothalamus

Cell lineage analysis, Hypothalamus, Radial glia, Retina, Tanycytes

Pak T, Yoo SY, Miranda-Angulo AM, Wang H, and Blackshaw S. PLoS ONE 2014, 9:e90381.

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Lhx2 is required for positioning of the eye field and patterning of the hypothalamus

Development, Hypothalamus, Lhx2, Retina, Spatial patterning

Roy A, de Melo J, Chaturvedi D, Thein T, Cabrera-Socorro A, Meyer G, Blackshaw S, Tole S. J Neurosci 2013 33:6877-84.

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Injury-independent induction of reactive gliosis in retinal Muller glia by loss of function of the LIM homeodomain transcription factor Lhx2

Lhx2, Muller glia, Neurodegeneration, Photoreceptor, Radial glia, Retina, Transcription factor

De Melo J, Miki K, Rattner A, Smallwood P, Hirokawa K, Monuki ES, Campochario P, and Blackshaw S. Proc Natl Acad Sci USA 2012 109:4657-62.

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The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity

Cell fate, Development, Retina, Transcription factor

Rapicavoli NA, Poth EM, Zhu H and Blackshaw S. Neural Dev 2011 6:23

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Sall3 controls retinal cone photoreceptor and horizontal cell development

Cell fate, Development, Photoreceptor, Retina, Transcription factor

De Melo J, Peng G-H, Chen S and Blackshaw S. Development 2011 138:2325-36.

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Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation

Photoreceptor, Retina, Transcription factor

Onishi A, Peng GH, Chen S, Blackshaw S. Nat Neurosci 2010 13:1059-65.

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The orphan nuclear hormone ERRb regulates rod photoreceptor development and survival

Neurodegeneration, Photoreceptor, Retina, Transcription factor

Onishi A, Peng G-H, Chen J, Lee DA, Alexis, U, Poth E, de Melo J, Chen S, and Blackshaw S. Proc Natl Acad Sci USA 2010 107:11579-84.

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The long noncoding RNA RNCR2 directs mouse retinal cell specification

Cell fate, Development, lncRNAs, Retina

Rapicavoli N, Poth E, Blackshaw S. BMC Dev Biol 2010 10:49

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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