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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Category: <span>Signal transduction</span>

Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus

Development, Hypothalamus, Signal transduction, Spatial patterning, Wnt

Newman EA, Wu D, Makoto MM, Zhang J, and Blackshaw S. Dev Biol, e-pub ahead of print.

Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Clark BS, and Blackshaw S. Sci Reports 2016 6:32757.

Link to Article>> View PDF>>

Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. J Neurosci 2016 36:2391-405.

Link to Article>> View PDF>>

Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer

Notch/Delta, Protein microarray, Proteomics, Signal transduction

Jung J, Stoeck A, Guan B, Wu RC, Zhu H, Blackshaw S, Shih IM, and Wang TL. PLoS Genetics 2014 10:e1004751.

Link to Article>> View PDF>>

Stage-specific inhibition of TrkB leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression

Metabolism, Signal transduction

Byerly MS, Swanson R, Wong GW and Blackshaw S. PLoS ONE 2013 8:e80781.

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Hypothalamic Neuron-derived Neurotrophic Factor (NENF) interacts with BDNF and melanocortin signaling to modulate food intake

Hypothalamus, Metabolism, Signal transduction

Byerly MS, Swanson R, Kwon K, Aja S, Moran TH, Wong GW, Blackshaw S. Am J Physiol 2013 304:R1085-95.

Link to Article>>

Construction of human activity-based phosphorylation networks

Protein microarray, Proteomics, Signal transduction

Newman RH, Hu J, Rho H-S, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Hu S, Hwang W, Jeong JS, Wu G, Jimmy Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov A, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J. Mol Sys Biol 2013 9:655.

Link to Article>> View PDF>>

Botch promotes neurogenesis by antagonizing Notch

Notch/Delta, Signal transduction

Chi Z, Zhang J, Tokunaga A, Harraz MM, Byrne ST, Dolinko A, Xu J, Blackshaw S, Gaiano N, Dawson TM, Dawson VL. Dev Cell 2012 22:707-20.

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Multi-faceted Regulation of Protein Kinase CK2 by Phosphorylation and Glycosylation Revealed through Semisynthesis

Protein microarray, Proteomics, Signal transduction

Tarrant MK, Rho HS, Xie Z , Jiang L, Gross C, Qian J, Ichikawa Y, Zachara N, Etzkorn F, Hart GW, Jeong JS, Blackshaw S, Zhu H, Cole PA. Nat Chem Biol 2012 8:262-91.

Link to Article>> View PDF>>

Muscleblind-like 2: Circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism

Circadian, RNA binding proteins, Signal transduction

Kim JS, Coon SL, Weller JL, Blackshaw S, Rath MF, Mrller M, Klein DC. J Neurochem 2009 110:756-64.

Link to Article>> View PDF>>

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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