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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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  • Research
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  • Research
  • Publications
  • Members
  • Datasets & Techniques

Category: <span>Sleep</span>

Winding the clock: development of hypothalamic neural circuitry controlling circadian timing and sleep

Circadian, Development, Hypothalamus, Review article, Sleep, Transcription factor

Kim DW and Blackshaw S. Masterclass in Developmental Neuroendocrinology, Springer, in press.

Lhx6-positive GABAergic neurons of the zona incerta promote sleep

Chemogenetics, Hypothalamus, Neural circuitry, Sleep, Transcription factor

Liu K, Kim J, Kim DW, Zhang S, Denaxa M, Bao H, Lim SA, Kim E, Liu C, Wickersham IR, Pachinis V, Hattar S, Song J, Brown SR, and Blackshaw S. Nature 2017 548:582-587.

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An Lhx1-Regulated Transcriptional Network Controls Sleep-Wake Coupling and Thermal Resistance of the Central Circadian Clockworks

Circadian, Hypothalamus, Sleep

Bedont JL, LeGates TA, Buhr E, Bathini A, Ling J, Wong P, van Gelder R, Mongrain V, Hattar S, and Blackshaw S. Curr Biol 2017 27:128-136.

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EphA4 is involved in sleep regulation but not in the electrophysiological response to sleep deprivation

Sleep

Freyburger M, Pierre A, Paquette G, Belanger-Nelson E, Bedont J, Gaudreault P-O, Rolet G, Laforest S, Blackshaw S, Cermakian N, Doucet G, and Mondrain V. Sleep 2016 39:613-24.

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Development of hypothalamic neural circuitry controlling circadian timing and sleep

Circadian, Development, Hypothalamus, Sleep

Bedont JL and Blackshaw S. Frontiers in Neuroscience, 2015 9:74.

WIDE AWAKE mediates the circadian timing of sleep onset

Hypothalamus, Sleep

Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont JL, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K, and Wu MN. Neuron 2014 82:151-6.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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