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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Category: <span>Transcription factor</span>

Lhx2 regulates temporal changes in chromatin accessibility and transcription factor binding in retinal progenitor cells

Lhx2, Neurogenesis, Retina, Transcription factor

Zibetti C, Liu S, Wan J, Qian J, Blackshaw S.

Link to Article>> View PDF>>

Winding the clock: development of hypothalamic neural circuitry controlling circadian timing and sleep

Circadian, Development, Hypothalamus, Review article, Sleep, Transcription factor

Kim DW and Blackshaw S. Masterclass in Developmental Neuroendocrinology, Springer, in press.

Comprehensive analysis of retinal development at single cell resolution identifies NFI factors as essential for mitotic exit and specification of late-born cells

Cell fate, Development, Neurogenesis, Retina, scRNA-Seq, Transcription factor, Transcriptomics

Clark BS, Stein-O’Brien GL, Shiau F, Cannon GH, Davis E, Sherman T, Rajaii F, James-Esposito RE, Gronostajski RM, Fertig EJ, Goff LA, and Blackshaw S. Neuron, in press.

Link to Article>> View PDF>>

Epigenomic profiling of retinal progenitors reveals LHX2 is required for developmental regulation of open chromatin

ATAC-Seq, ChIP-Seq, Development, Lhx2, Retina, Transcription factor

Zibetti C, Liu S, Wan J, Qian J, and Blackshaw S. Comm Biology 2019, 2:142.

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Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes

Development, Hypothalamus, Spatial patterning, Transcription factor

Newman EA, Wan J, Wang J, Jiang, Qian J, and Blackshaw S. Dev Biol 2018 439:102-111

Link to Article>>

Pax6 is essential for generation of late born retinal neurons and for inhibition of photoreceptor fate during late stages of retinogenesis in mammals

Cell fate, Development, Retina, Transcription factor

Remizova L Onishi A, Blackshaw S, Zack D, and Ashery-Padan R. Dev Biol 2017 432:140-150.

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BPAC: A universal model for prediction of transcription factor binding sites based on chromatin accessibility

ATAC-Seq, New technique, Transcription factor

Liu S, Zibetti C, Wan J, Wang G, Blackshaw S, and Qian J. BMC Bioinformatics 2017 18:355.

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Lhx6-positive GABAergic neurons of the zona incerta promote sleep

Chemogenetics, Hypothalamus, Neural circuitry, Sleep, Transcription factor

Liu K, Kim J, Kim DW, Zhang S, Denaxa M, Bao H, Lim SA, Kim E, Liu C, Wickersham IR, Pachinis V, Hattar S, Song J, Brown SR, and Blackshaw S. Nature 2017 548:582-587.

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Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Clark BS, and Blackshaw S. Sci Reports 2016 6:32757.

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Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling

Cell fate, Development, Lhx2, Muller glia, Neurogenesis, Notch/Delta, Radial glia, Retina, Signal transduction, Transcription factor

De Melo J, Zibetti C, Clark BS, Hwang W, Miranda-Angulo AL, Qian J, Blackshaw S. J Neurosci 2016 36:2391-405.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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