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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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Category: <span>Transcription factor</span>

A conserved regulatory logic controls temporal identity in mouse neural progenitors

Cell fate, Development, Retina, Transcription factor

Mattar P, Ericson J, Blackshaw S, and Cayouette M. Neuron 2015 85:497-504.

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The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation

Cell fate, Development, Lhx2, Tanycytes, Transcription factor

Salvatierra J, Lee DA, Zibetti C, Duran-Moreno M, Yoo S, Newman EA, Wang H, Bedont JL, de Melo J, Miranda-Angulo AL, Gil-Perotin S, Garcia-Verdugo JM, and Blackshaw S. J Neurosci 2014 34:16809-20.

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Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus

Circadian, Development, Hypothalamus, Nucleogenesis, Suprachiasmatic nucleus, Transcription factor

Bedont JL, LeGates TA, Slat EA , Byerly MS, Wang H, Hu J, Rupp AC, Qian J, Wong GW, Herzog ED, Hattar S, and Blackshaw S. Cell Reports 2014 7:609-22.

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ERRb deficiency alters body composition and response to stress

Metabolism, Transcription factor

Byerly MS, Swanson R, Wong GW, Blackshaw S. BMC Physiology 2013 13:10.

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Rax regulates hypothalamic tanycyte differentiation and barrier function in mice

Development, Radial glia, Tanycytes, Transcription factor

Miranda-Angulo AM, Byerly MS, Wang H, Messa J, Blackshaw S. J Comp Neurol 2013, 522:876-99.

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Estrogen-related receptor β regulates whole body energy balance and modulates neuropeptide Y expression

Metabolism, Transcription factor

Byerly MS, Al Salayta M, Kwon K, Swanson R, Peterson JM, Wei Z, Aja S, Moran TH, Blackshaw S, Wong GW. Eur J Neurosci 2013 37:1033-47.

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Injury-independent induction of reactive gliosis in retinal Muller glia by loss of function of the LIM homeodomain transcription factor Lhx2

Lhx2, Muller glia, Neurodegeneration, Photoreceptor, Radial glia, Retina, Transcription factor

De Melo J, Miki K, Rattner A, Smallwood P, Hirokawa K, Monuki ES, Campochario P, and Blackshaw S. Proc Natl Acad Sci USA 2012 109:4657-62.

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Yeast one-hybrid assays for high-throughoutput human gene regulatory network mapping

New technique, Transcription factor

Barutcu1 AR, Reece-Hoyes JS, McCord RP, Jeong J, Jiang L, MacWilliams A, Yang X, Salehi-Ashtiani K, Hill DE, Blackshaw S, Zhu H, Dekker J and Walhout AJM. Nat Methods 2011 8:1050-2

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The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity

Cell fate, Development, Retina, Transcription factor

Rapicavoli NA, Poth EM, Zhu H and Blackshaw S. Neural Dev 2011 6:23

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Sall3 controls retinal cone photoreceptor and horizontal cell development

Cell fate, Development, Photoreceptor, Retina, Transcription factor

De Melo J, Peng G-H, Chen S and Blackshaw S. Development 2011 138:2325-36.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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