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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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  • Research
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  • Research
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Serine racemase regulated by binding to stargazin and PSD-95: potential NMDA-AMPA glutamate neurotransmission cross-talk

D-Amino acids, Protein microarray, Proteomics

Ma TM, Paul BD, Fu C, Hu S, Zhu H, Blackshaw S, Wolosker H, and Snyder SH. J Biol Chem 2014 289:29631-41.

Link to Article>> View PDF>>

Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers in ZNF261 and ZNF198

Protein microarray, Proteomics, SUMOylation

Guzzo CM, Ringel A, Cox E, Uzoma I, Zhu H, Blackshaw S, Wolberger C, and Matunis MJ. 2014 PLoS ONE 2014 9:e105271.

Link to Article>> View PDF>>

Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice

Hypothalamus, Neurogenesis, Tanycytes

Lee DA, Yoo S, Pak T, Salvatierra J, Velarde E, Aja S, and Blackshaw S. Front Neurosci 2014 8:15

Link to Article>> View PDF>>

Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus

Circadian, Development, Hypothalamus, Nucleogenesis, Suprachiasmatic nucleus, Transcription factor

Bedont JL, LeGates TA, Slat EA , Byerly MS, Wang H, Hu J, Rupp AC, Qian J, Wong GW, Herzog ED, Hattar S, and Blackshaw S. Cell Reports 2014 7:609-22.

Link to Article>> View PDF>>

WIDE AWAKE mediates the circadian timing of sleep onset

Hypothalamus, Sleep

Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont JL, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K, and Wu MN. Neuron 2014 82:151-6.

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Rax-CreERT2 knock-in mice: a tool for selective and conditional gene deletion in progenitors and radial glia of the retina and hypothalamus

Cell lineage analysis, Hypothalamus, Radial glia, Retina, Tanycytes

Pak T, Yoo SY, Miranda-Angulo AM, Wang H, and Blackshaw S. PLoS ONE 2014, 9:e90381.

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Long noncoding RNA-dependent transcriptional regulation in neuronal development and disease

Development, lncRNAs, Review article

Clark BS and Blackshaw S. Frontiers in Genetics, 2014 5:164.

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Stage-specific inhibition of TrkB leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression

Metabolism, Signal transduction

Byerly MS, Swanson R, Wong GW and Blackshaw S. PLoS ONE 2013 8:e80781.

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Feed your head: neurodevelopmental regulation of metabolism

Development, Hypothalamus, Neurogenesis, Review article

Lee DA and Blackshaw S. Annual Review of Physiology, 2014 76:197-223.

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High-throughput in situ hybridization in mouse retina

Protocol, Transcriptomics

Blackshaw S. 2013 Methods Mol Biol 935:215-26.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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