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Blackshaw Lab

Building and Rebuilding the Retina and Hypothalamus

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RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention

Neurodegeneration, Protein microarray, Proteomics, RNA binding proteins

Donnelly CJ, Zhang P, Pham JT, Heusler A, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Margakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennet CF, Blackshaw S, Sattler R, and Rothestein JD. Neuron 2013 80:415-28.

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Characterization of the S-Nitrosoproteome reveals an S-Nitrosylation Motif and a family of NO-regulated E3 ubiquitin ligases

Nitric oxide, Protein microarray, Proteomics

Lee YI, Giovinazzo D, Kang HC, Lee Y, Jeong JS, Doulias PT, Xie Z, Ischiropoulos H, Zhu H, Blackshaw S, Dawson VL, Dawson TM. Mol Cell Proteomics 2013 13:63-72

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ERRb deficiency alters body composition and response to stress

Metabolism, Transcription factor

Byerly MS, Swanson R, Wong GW, Blackshaw S. BMC Physiology 2013 13:10.

Link to Article>>

Probing the functional role of adult hypothalamic neurogenesis by computer tomography image guided focal irradiation

Hypothalamus, Neurogenesis, Protocol

Lee DA, Salvatierra J, Velarde E, Wong J, Ford E, Blackshaw S. JoVE 2013 14: 10.379/50716.

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Rax regulates hypothalamic tanycyte differentiation and barrier function in mice

Development, Radial glia, Tanycytes, Transcription factor

Miranda-Angulo AM, Byerly MS, Wang H, Messa J, Blackshaw S. J Comp Neurol 2013, 522:876-99.

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BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity

Protein microarray, Proteomics

Chen Y, Yang LN, Cheng L, Shun T, Guo SJ, Le HY, Xiong Q, Mo R, Li CY, Jeong JS, Jiang L, Blackshaw S, Bi LJ, Zhu H, Tao SC, Ge F. Mol Cell Proteomics 2013 12:2804-19.

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The long non-coding RNA Gomafu is involved in neuronal activation and schizophrenia-associated alternative splicing

lncRNAs, Protein microarray

Barry G, Briggs J, Poth EM, Vanichkina , Ratnu VS, Nayler SP, Nones K, Bredy TW, Nakagawa S, Blackshaw S, Wolvetang EJ, Mattick JS. Mol Psych 2013 19:486-94.

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Lhx2 is required for positioning of the eye field and patterning of the hypothalamus

Development, Hypothalamus, Lhx2, Retina, Spatial patterning

Roy A, de Melo J, Chaturvedi D, Thein T, Cabrera-Socorro A, Meyer G, Blackshaw S, Tole S. J Neurosci 2013 33:6877-84.

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Hypothalamic Neuron-derived Neurotrophic Factor (NENF) interacts with BDNF and melanocortin signaling to modulate food intake

Hypothalamus, Metabolism, Signal transduction

Byerly MS, Swanson R, Kwon K, Aja S, Moran TH, Wong GW, Blackshaw S. Am J Physiol 2013 304:R1085-95.

Link to Article>>

Construction of human activity-based phosphorylation networks

Protein microarray, Proteomics, Signal transduction

Newman RH, Hu J, Rho H-S, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Hu S, Hwang W, Jeong JS, Wu G, Jimmy Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov A, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J. Mol Sys Biol 2013 9:655.

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Research Areas

  • AAV
  • Antibody specificity
  • ATAC-Seq
  • Autoimmune disease
  • Behavior
  • Book Chapter
  • Cell fate
  • Cell lineage analysis
  • Chemical senses
  • Chemogenetics
  • ChIP-Seq
  • Circadian
  • Commentary
  • D-Amino acids
  • Development
  • Diabetes
  • Extraretinal photoreceptors
  • FGF
  • Human genetics
  • Hypothalamus
  • In vivo electroporation
  • Lens
  • Lhx2
  • lncRNAs
  • Metabolism
  • Muller glia
  • Neural circuitry
  • Neural development
  • Neurodegeneration
  • Neurogenesis
  • Neurotransmitters
  • New technique
  • Nitric oxide
  • Notch/Delta
  • Nucleogenesis
  • Photoreceptor
  • Protein microarray
  • Proteomics
  • Protocol
  • Radial glia
  • Retina
  • Review article
  • RNA binding proteins
  • RNA splicing
  • RPE
  • SAGE
  • scRNA-Seq
  • Shh
  • Signal transduction
  • Sleep
  • Spatial patterning
  • SUMOylation
  • Suprachiasmatic nucleus
  • Tanycytes
  • Thalamus
  • Transcription factor
  • Transcriptomics
  • Visual cycle
  • Wnt

Recent Posts

  • Cell-specific regulation of gene expression using splicing-dependent frameshifting
  • Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
  • LRLoop: A method to predict feedback loops in cell-cell communication
  • Notch Inhibition Promotes Regeneration and Immunosuppression Supports Cone Survival in a Zebrafish Model of Inherited Retinal Dystrophy
  • Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina

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